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NullHypo

NullHypo.

Practical AI content for HEOR and Market Access professionals, built by someone who does this work, for people who do this work.

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The null hypothesis is that AI cannot meaningfully transform HEOR and Market Access work.

We reject it. With evidence.
Shubhram Pandey
Who builds this

Shubhram Pandey is an HEOR and Market Access professional with deep hands-on experience across health economic modelling, statistical analysis, evidence synthesis, and HTA submissions. For the last few years, building and stress-testing AI pipelines for the same work. Every claim on NullHypo is tested like a hypothesis.

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What we cover
Domain 01
Evidence Synthesis
Systematic literature reviews, network meta-analyses, indirect treatment comparisons, and MAICs, covering practical AI workflows for the evidence work that underpins every HTA submission.
Domain 02
Real-World Evidence & Biostatistics
Clinical trial analysis, RWE from EHR and claims databases, PRO analysis, and survival analysis. AI accelerates parts of this work; statistical rigour must remain non-negotiable.
Domain 03
Health Economic Modelling
Model conceptualisation, development, and validation, from early decision-analytic frameworks through to submission-ready Markov and partitioned survival models. Where AI helps and where it creates risk.
Domain 04
HTA Evidence & Submissions
Dossier development and submission strategy for NICE, CADTH, EU-HTA, and global HTA bodies. This covers how AI fits into the evidence assembly process and what responsible use looks like in a regulatory context.
Domain 05
Market Access Strategy
Payer intelligence, HTA signal interpretation, and value story development, with AI as a strategic thinking partner for the market access decisions that directly affect reimbursement outcomes.
Domain 06
Prompting & Pipelines
Practical prompting techniques, tool benchmarks tested on real HEOR tasks, and end-to-end pipeline builds, with the architecture, the code, and failure modes included.
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